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TRIMETHYLACETIC ANHYDRIDE

Trimethylacetic anhydride

CAS: 1538-75-6

Molecular Formula: C10H18O3

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TRIMETHYLACETIC ANHYDRIDE - Names and Identifiers

Name Trimethylacetic anhydride
Synonyms Pivalic anhydride
Bis(pivalic)anhydride
Trimethylacetic anhydride
Bis(pivalic acid)anhydride
BIS(TRIMETHYLACETIC) ANHYDRIDE
2,2-dimethylpropanoic anhydride
2,2-DIMETHYLPROPIONIC ANHYDRIDE
Bis(2,2-dimethylpropionic)anhydride
2,2-DIMETHYLPROPIONIC ACID ANHYDRIDE
Bis(2,2-dimethylpropionic acid)anhydride
2,2-Dimethylpropionic anhydride, Pivalic anhydride
CAS 1538-75-6
EINECS 216-263-1
InChI InChI=1/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3

TRIMETHYLACETIC ANHYDRIDE - Physico-chemical Properties

Molecular FormulaC10H18O3
Molar Mass186.25
Density0.918g/mLat 25°C(lit.)
Boling Point193°C(lit.)
Flash Point135°F
Solubility Miscible with acetonitrile.
Vapor Presure62.1Pa at 25℃
AppearanceLiquid
ColorClear colorless
BRN386552
Storage ConditionInert atmosphere,Room Temperature
SensitiveMoisture Sensitive
Refractive Indexn20/D 1.409(lit.)

TRIMETHYLACETIC ANHYDRIDE - Risk and Safety

Hazard SymbolsC - Corrosive
Corrosive
Risk Codes34 - Causes burns
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDsUN 2920 8/PG 2
WGK Germany3
FLUKA BRAND F CODES9-13-21
TSCAYes
HS Code29159000
Hazard Class8
Packing GroupII

TRIMETHYLACETIC ANHYDRIDE - Reference Information

LogP2.15
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
uses pivalic anhydride is a metabolite of the dual prodrug of ganciclovir (6-dgc V-dpiv).
synthetic use trimethylacetic anhydride is used as an acylating and esterifying agent, which participates in acylation and esterification reactions with aniline and phenol. Trimethylacetic anhydride is also used for solid-phase oligonucleotide synthesis and kinetic resolution of racemic 2-hydroxy-γ-butyrolactone and diphenylacetic acid for the production of cyano-4, N-tert-butoxycarbonyl piperidine, it is also used in solid-phase oligonucleotide synthesis.
preparation currently, the synthesis of trimethyl acetic anhydride from pivalic acid is mainly realized by dehydrating agent or under the action of acetic anhydride. This method requires the use of dehydrating agents with serious environmental pollution, and has a long production process route, many processes, high investment in equipment and capital construction, and high requirements for corrosion resistance of the equipment. If the exchange dehydration reaction is carried out with acetic anhydride, a longer reaction time is required. It is of great significance to systematically study the preparation process of trimethyl acetic anhydride. The synthesis reaction formula of trimethyl acetic anhydride is shown below: Fig. 1
Last Update：2024-04-09 02:00:04
TRIMETHYLACETIC ANHYDRIDE
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Trimethylacetic anhydride Request for quotation
CAS: 1538-75-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Trimethylacetic anhydride Request for quotation
CAS: 1538-75-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name:  Trimethylacetic anhydride Request for quotation
CAS: 1538-75-6
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Handan Huajun Chemicals Co.,Ltd
Product Name: Trimethylacetic anhydride Request for quotation
CAS: 1538-75-6
Tel:
Email: hdhjchem@yeah.net
Mobile: 18630058311
QQ: 573631441 Click to send a QQ messageSend QQ message
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TRIMETHYLACETIC ANHYDRIDE
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